Title |
Forward chemical genetic screens in Arabidopsis identify genes that influence sensitivity to the phytotoxic compound sulfamethoxazole
|
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Published in |
BMC Plant Biology, November 2012
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DOI | 10.1186/1471-2229-12-226 |
Pubmed ID | |
Authors |
Karl J Schreiber, Ryan S Austin, Yunchen Gong, Jianfeng Zhang, Pauline Fung, Pauline W Wang, David S Guttman, Darrell Desveaux |
Abstract |
The sulfanilamide family comprises a clinically important group of antimicrobial compounds which also display bioactivity in plants. While there is evidence that sulfanilamides inhibit folate biosynthesis in both bacteria and plants, the complete network of plant responses to these compounds remains to be characterized. As such, we initiated two forward genetic screens in Arabidopsis in order to identify mutants that exhibit altered sensitivity to sulfanilamide compounds. These screens were based on the growth phenotype of seedlings germinated in the presence of the compound sulfamethoxazole (Smex). |
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