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Aqueous humor polymerase chain reaction in uveitis – utility and safety

Overview of attention for article published in BMC Ophthalmology, October 2016
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Title
Aqueous humor polymerase chain reaction in uveitis – utility and safety
Published in
BMC Ophthalmology, October 2016
DOI 10.1186/s12886-016-0369-z
Pubmed ID
Authors

Argyrios Chronopoulos, Daniel Roquelaure, Georges Souteyrand, Jörg Dieter Seebach, James Scott Schutz, Gabriele Thumann

Abstract

To study the value and safety of aqueous humor polymerase chain reaction (PCR) analysis for Herpes simplex, varicella zoster, cytomegalovirus, Epstein-Barr virus and Toxoplasma gondii in patients with uveitis. Records of 45 consecutive patients with anterior and posterior uveitis who underwent AC paracentesis with PCR were reviewed. The main outcome measure was frequency of PCR positivity. Secondary outcomes were alteration of treatment, safety of paracentesis, and correlation of keratitic precipitates with PCR positivity, RESULTS: The overall PCR positivity was 48.9 % (22/45). Therapy was changed because of the PCR results in 14/45 patients (37.7 %). One patient experienced a paracentesis related complication (1/45, 2.2 %) without long-term sequelae. Aqueous PCR altered the diagnosis and treatment in over a third of our patients and was relatively safe. Aqueous PCR should be considered for uveitis of atypical clinical appearance, recurrent severe uveitis of uncertain etiology, and therapy refractory cases.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 2%
Unknown 43 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 16%
Student > Postgraduate 5 11%
Student > Ph. D. Student 5 11%
Professor 5 11%
Student > Bachelor 5 11%
Other 14 32%
Unknown 3 7%
Readers by discipline Count As %
Medicine and Dentistry 29 66%
Agricultural and Biological Sciences 4 9%
Biochemistry, Genetics and Molecular Biology 2 5%
Nursing and Health Professions 2 5%
Immunology and Microbiology 2 5%
Other 3 7%
Unknown 2 5%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2016.
All research outputs
#20,418,183
of 22,968,808 outputs
Outputs from BMC Ophthalmology
#2,110
of 2,371 outputs
Outputs of similar age
#271,587
of 314,253 outputs
Outputs of similar age from BMC Ophthalmology
#19
of 22 outputs
Altmetric has tracked 22,968,808 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,371 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,253 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.