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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Asymptomatic Plasmodium vivax infections induce robust IgG responses to multiple blood-stage proteins in a low-transmission region of western Thailand
|
|---|---|
| Published in |
Malaria Journal, April 2017
|
| DOI | 10.1186/s12936-017-1826-8 |
| Pubmed ID | |
| Authors |
Rhea J. Longley, Camila T. França, Michael T. White, Chalermpon Kumpitak, Patiwat Sa-angchai, Jakub Gruszczyk, Jessica B. Hostetler, Anjali Yadava, Christopher L. King, Rick M. Fairhurst, Julian C. Rayner, Wai-Hong Tham, Wang Nguitragool, Jetsumon Sattabongkot, Ivo Mueller |
| Abstract |
Thailand is aiming to eliminate malaria by the year 2024. Plasmodium vivax has now become the dominant species causing malaria within the country, and a high proportion of infections are asymptomatic. A better understanding of antibody dynamics to P. vivax antigens in a low-transmission setting, where acquired immune responses are poorly characterized, will be pivotal for developing new strategies for elimination, such as improved surveillance methods and vaccines. The objective of this study was to characterize total IgG antibody levels to 11 key P. vivax proteins in a village of western Thailand. Plasma samples from 546 volunteers enrolled in a cross-sectional survey conducted in 2012 in Kanchanaburi Province were utilized. Total IgG levels to 11 different proteins known or predicted to be involved in reticulocyte binding or invasion (ARP, GAMA, P41, P12, PVX_081550, and five members of the PvRBP family), as well as the leading pre-erythrocytic vaccine candidate (CSP) were measured using a multiplexed bead-based assay. Associations between IgG levels and infection status, age, and spatial location were explored. Individuals from a low-transmission region of western Thailand reacted to all 11 P. vivax recombinant proteins. Significantly greater IgG levels were observed in the presence of a current P. vivax infection, despite all infected individuals being asymptomatic. IgG levels were also higher in adults (18 years and older) than in children. For most of the proteins, higher IgG levels were observed in individuals living closer to the Myanmar border and further away from local health services. Robust IgG responses were observed to most proteins and IgG levels correlated with surrogates of exposure, suggesting these antigens may serve as potential biomarkers of exposure, immunity, or both. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 20% |
| United Kingdom | 1 | 5% |
| Nigeria | 1 | 5% |
| Spain | 1 | 5% |
| Australia | 1 | 5% |
| Belgium | 1 | 5% |
| Japan | 1 | 5% |
| Italy | 1 | 5% |
| Switzerland | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 7 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 40% |
| Scientists | 8 | 40% |
| Practitioners (doctors, other healthcare professionals) | 2 | 10% |
| Science communicators (journalists, bloggers, editors) | 2 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 2% |
| Unknown | 59 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 22% |
| Student > Ph. D. Student | 10 | 17% |
| Student > Master | 9 | 15% |
| Lecturer | 2 | 3% |
| Professor | 2 | 3% |
| Other | 4 | 7% |
| Unknown | 20 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 22% |
| Immunology and Microbiology | 7 | 12% |
| Biochemistry, Genetics and Molecular Biology | 5 | 8% |
| Nursing and Health Professions | 3 | 5% |
| Agricultural and Biological Sciences | 2 | 3% |
| Other | 6 | 10% |
| Unknown | 24 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2017.
All research outputs
#2,657,937
of 24,580,204 outputs
Outputs from Malaria Journal
#567
of 5,786 outputs
Outputs of similar age
#48,236
of 315,148 outputs
Outputs of similar age from Malaria Journal
#20
of 132 outputs
Altmetric has tracked 24,580,204 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,786 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,148 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 132 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.