Title |
Oxidative stress disruption of receptor-mediated calcium signaling mechanisms
|
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Published in |
Journal of Biomedical Science, July 2013
|
DOI | 10.1186/1423-0127-20-48 |
Pubmed ID | |
Authors |
Tso-Hao Tang, Chiung-Tan Chang, Hsiu-Jen Wang, Joshua D Erickson, Rhett A Reichard, Alexis G Martin, Erica K Shannon, Adam L Martin, Yue-Wern Huang, Robert S Aronstam |
Abstract |
Oxidative stress increases the cytosolic content of calcium in the cytoplasm through a combination of effects on calcium pumps, exchangers, channels and binding proteins. In this study, oxidative stress was produced by exposure to tert-butyl hydroperoxide (tBHP); cell viability was assessed using a dye reduction assay; receptor binding was characterized using [3H]N-methylscopolamine ([3H]MS); and cytosolic and luminal endoplasmic reticulum (ER) calcium concentrations ([Ca2+]i and [Ca2+]L, respectively) were measured by fluorescent imaging. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 45 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 19% |
Student > Bachelor | 9 | 19% |
Student > Ph. D. Student | 6 | 13% |
Student > Master | 6 | 13% |
Student > Doctoral Student | 3 | 6% |
Other | 6 | 13% |
Unknown | 8 | 17% |
Readers by discipline | Count | As % |
---|---|---|
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Medicine and Dentistry | 4 | 9% |
Neuroscience | 3 | 6% |
Business, Management and Accounting | 1 | 2% |
Other | 6 | 13% |
Unknown | 9 | 19% |