Title |
Yokukansan promotes hippocampal neurogenesis associated with the suppression of activated microglia in Gunn rat
|
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Published in |
Journal of Neuroinflammation, December 2013
|
DOI | 10.1186/1742-2094-10-145 |
Pubmed ID | |
Authors |
Motohide Furuya, Tsuyoshi Miyaoka, Toshiko Tsumori, Kristian Liaury, Sadayuki Hashioka, Rei Wake, Keiko Tsuchie, Michiyo Fukushima, Satoko Ezoe, Jun Horiguchi |
Abstract |
The pathophysiology of schizophrenia (SCZ) remains unclear, and its treatment is far from ideal. We have previously reported that yokukansan (YKS), which is a traditional Japanese medicine, is effective as an adjunctive therapy for SCZ. However, the mechanisms underlying the action of YKS have not yet been completely elucidated. A recent meta-analysis study has shown that adjuvant anti-inflammatory drugs are effective for SCZ treatment, and it has been proposed that some of the cognitive deficits associated with inflammation may in part be related to inflammation-induced reductions in adult hippocampal neurogenesis. Although certain ingredients of YKS have potent anti-inflammatory activity, no study has determined if YKS has anti-inflammatory properties. |
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Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 3% |
Unknown | 36 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 14% |
Student > Bachelor | 5 | 14% |
Researcher | 4 | 11% |
Student > Master | 3 | 8% |
Other | 2 | 5% |
Other | 5 | 14% |
Unknown | 13 | 35% |
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Neuroscience | 8 | 22% |
Medicine and Dentistry | 8 | 22% |
Agricultural and Biological Sciences | 3 | 8% |
Psychology | 1 | 3% |
Environmental Science | 1 | 3% |
Other | 2 | 5% |
Unknown | 14 | 38% |