Title |
c-Jun N-terminal kinase in synergistic neurite outgrowth in PC12 cells mediated through P90RSK
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Published in |
BMC Neuroscience, December 2013
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DOI | 10.1186/1471-2202-14-153 |
Pubmed ID | |
Authors |
Kok Huei Seow, Lihan Zhou, Gregory Stephanopoulos, Heng-Phon Too |
Abstract |
Synergistic multi-ligand treatments that can induce neuronal differentiation offer valuable strategies to regulate and modulate neurite outgrowth. Whereas the signaling pathways mediating single ligand-induced neurite outgrowth, such as Akt, extracellular signal-regulated kinase (Erk), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (P38), have been extensively studied, the mechanisms underlying multi-ligand synergistic neurite outgrowth are poorly understood. In an attempt to gain insight into synergistic neurite outgrowth, PC12 cells were treated with one of three combinations: pituitary adenylate cyclase-activating peptide (PACAP) with epidermal growth factor (EP), basic fibroblast growth factor (FP), or nerve growth factor (NP) and then challenged with the appropriate kinase inhibitors to assess the signaling pathways involved in the process. |
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United Kingdom | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 24% |
Student > Ph. D. Student | 2 | 10% |
Student > Doctoral Student | 1 | 5% |
Student > Bachelor | 1 | 5% |
Lecturer | 1 | 5% |
Other | 3 | 14% |
Unknown | 8 | 38% |
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Agricultural and Biological Sciences | 3 | 14% |
Nursing and Health Professions | 1 | 5% |
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Medicine and Dentistry | 1 | 5% |
Other | 1 | 5% |
Unknown | 9 | 43% |