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c-Jun N-terminal kinase in synergistic neurite outgrowth in PC12 cells mediated through P90RSK

Overview of attention for article published in BMC Neuroscience, December 2013
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Title
c-Jun N-terminal kinase in synergistic neurite outgrowth in PC12 cells mediated through P90RSK
Published in
BMC Neuroscience, December 2013
DOI 10.1186/1471-2202-14-153
Pubmed ID
Authors

Kok Huei Seow, Lihan Zhou, Gregory Stephanopoulos, Heng-Phon Too

Abstract

Synergistic multi-ligand treatments that can induce neuronal differentiation offer valuable strategies to regulate and modulate neurite outgrowth. Whereas the signaling pathways mediating single ligand-induced neurite outgrowth, such as Akt, extracellular signal-regulated kinase (Erk), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (P38), have been extensively studied, the mechanisms underlying multi-ligand synergistic neurite outgrowth are poorly understood. In an attempt to gain insight into synergistic neurite outgrowth, PC12 cells were treated with one of three combinations: pituitary adenylate cyclase-activating peptide (PACAP) with epidermal growth factor (EP), basic fibroblast growth factor (FP), or nerve growth factor (NP) and then challenged with the appropriate kinase inhibitors to assess the signaling pathways involved in the process.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 24%
Student > Ph. D. Student 2 10%
Student > Doctoral Student 1 5%
Student > Bachelor 1 5%
Lecturer 1 5%
Other 3 14%
Unknown 8 38%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 24%
Agricultural and Biological Sciences 3 14%
Nursing and Health Professions 1 5%
Social Sciences 1 5%
Medicine and Dentistry 1 5%
Other 1 5%
Unknown 9 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2013.
All research outputs
#20,213,623
of 22,736,112 outputs
Outputs from BMC Neuroscience
#1,052
of 1,241 outputs
Outputs of similar age
#267,114
of 307,106 outputs
Outputs of similar age from BMC Neuroscience
#33
of 35 outputs
Altmetric has tracked 22,736,112 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,241 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,106 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.