Title |
Hypotheses, rationale, design, and methods for evaluation of ischemic preconditioning assessed by sequential exercise tests in diabetic and non-diabetic patients with stable coronary artery disease – a prospective study
|
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Published in |
BMC Cardiovascular Disorders, December 2013
|
DOI | 10.1186/1471-2261-13-117 |
Pubmed ID | |
Authors |
Paulo Cury Rezende, Rosa Maria Rahmi Garcia, Augusto Hiroshi Uchida, Leandro Menezes Alves Costa, Thiago Luis Scudeler, Rodrigo Morel Vieira Melo, Fernando Teiichi Costa Oikawa, Cibele Larrosa Garzillo, Eduardo Gomes Lima, Carlos Alexandre Wainrober Segre, Desiderio Favarato, Priscyla Girardi, Myrthes Takiuti, Celia Cassaro Strunz, Whady Hueb, José Antonio Franchini Ramires, Roberto Kalil Filho |
Abstract |
Ischemic preconditioning is a powerful mechanism of myocardial protection and in humans it can be evaluated by sequential exercise tests. Coronary Artery Disease in the presence of diabetes mellitus may be associated with worse outcomes. In addition, some studies have shown that diabetes interferes negatively with the development of ischemic preconditioning. However, it is still unknown whether diabetes may influence the expression of ischemic preconditioning in patients with stable multivessel coronary artery disease. |
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