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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis
|
|---|---|
| Published in |
Breast Cancer Research, December 2013
|
| DOI | 10.1186/bcr3585 |
| Pubmed ID | |
| Authors |
Katrien Van Impe, Jonas Bethuyne, Steven Cool, Francis Impens, David Ruano-Gallego, Olivier De Wever, Berlinda Vanloo, Marleen Van Troys, Kathleen Lambein, Ciska Boucherie, Evelien Martens, Olivier Zwaenepoel, Gholamreza Hassanzadeh-Ghassabeh, Joël Vandekerckhove, Kris Gevaert, Luis Ángel Fernández, Niek N Sanders, Jan Gettemans |
| Abstract |
Aberrant turnover of the actin cytoskeleton is intimately associated with cancer cell migration and invasion. Frequently however, evidence is circumstantial, and a reliable assessment of the therapeutic significance of a gene product is offset by lack of inhibitors that target biologic properties of a protein, as most conventional drugs do, instead of the corresponding gene. Proteomic studies have demonstrated overexpression of CapG, a constituent of the actin cytoskeleton, in breast cancer. Indirect evidence suggests that CapG is involved in tumor cell dissemination and metastasis. In this study, we used llama-derived CapG single-domain antibodies or nanobodies in a breast cancer metastasis model to address whether inhibition of CapG activity holds therapeutic merit. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | <1% |
| Japan | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 106 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 23 | 21% |
| Student > Ph. D. Student | 22 | 20% |
| Student > Master | 16 | 15% |
| Student > Bachelor | 12 | 11% |
| Other | 7 | 6% |
| Other | 12 | 11% |
| Unknown | 17 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 31 | 28% |
| Agricultural and Biological Sciences | 23 | 21% |
| Medicine and Dentistry | 7 | 6% |
| Immunology and Microbiology | 6 | 6% |
| Chemistry | 5 | 5% |
| Other | 18 | 17% |
| Unknown | 19 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2023.
All research outputs
#4,659,861
of 25,374,647 outputs
Outputs from Breast Cancer Research
#533
of 2,053 outputs
Outputs of similar age
#51,048
of 320,433 outputs
Outputs of similar age from Breast Cancer Research
#10
of 38 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,053 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,433 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.