Title |
A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis
|
---|---|
Published in |
Breast Cancer Research, December 2013
|
DOI | 10.1186/bcr3585 |
Pubmed ID | |
Authors |
Katrien Van Impe, Jonas Bethuyne, Steven Cool, Francis Impens, David Ruano-Gallego, Olivier De Wever, Berlinda Vanloo, Marleen Van Troys, Kathleen Lambein, Ciska Boucherie, Evelien Martens, Olivier Zwaenepoel, Gholamreza Hassanzadeh-Ghassabeh, Joël Vandekerckhove, Kris Gevaert, Luis Ángel Fernández, Niek N Sanders, Jan Gettemans |
Abstract |
Aberrant turnover of the actin cytoskeleton is intimately associated with cancer cell migration and invasion. Frequently however, evidence is circumstantial, and a reliable assessment of the therapeutic significance of a gene product is offset by lack of inhibitors that target biologic properties of a protein, as most conventional drugs do, instead of the corresponding gene. Proteomic studies have demonstrated overexpression of CapG, a constituent of the actin cytoskeleton, in breast cancer. Indirect evidence suggests that CapG is involved in tumor cell dissemination and metastasis. In this study, we used llama-derived CapG single-domain antibodies or nanobodies in a breast cancer metastasis model to address whether inhibition of CapG activity holds therapeutic merit. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Belgium | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Iran, Islamic Republic of | 1 | <1% |
Japan | 1 | <1% |
Germany | 1 | <1% |
Unknown | 105 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 23 | 21% |
Student > Ph. D. Student | 22 | 20% |
Student > Master | 16 | 15% |
Student > Bachelor | 12 | 11% |
Other | 7 | 6% |
Other | 9 | 8% |
Unknown | 19 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 31 | 29% |
Agricultural and Biological Sciences | 23 | 21% |
Medicine and Dentistry | 7 | 6% |
Immunology and Microbiology | 6 | 6% |
Chemistry | 5 | 5% |
Other | 15 | 14% |
Unknown | 21 | 19% |