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Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study

Overview of attention for article published in BMC Cancer, November 2009
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1 X user
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1 Facebook page

Citations

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89 Dimensions

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92 Mendeley
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Title
Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study
Published in
BMC Cancer, November 2009
DOI 10.1186/1471-2407-9-407
Pubmed ID
Authors

Vibeke Andersen, Mette Østergaard, Jane Christensen, Kim Overvad, Anne Tjønneland, Ulla Vogel

Abstract

The xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH). Cyclooxygenase-2 (COX-2) derived prostaglandins promote gastrointestinal carcinogenesis, affecting angiogenesis, apoptosis, and invasiveness.The aim of this study was to investigate if polymorphisms in these genes were associated with risk of colorectal cancer (CRC), and to investigate possible interactions with lifestyle factors such as smoking, meat consumption, and NSAID use.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 2%
Unknown 90 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 26 28%
Student > Ph. D. Student 21 23%
Researcher 7 8%
Student > Bachelor 7 8%
Student > Doctoral Student 4 4%
Other 16 17%
Unknown 11 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 25%
Medicine and Dentistry 21 23%
Biochemistry, Genetics and Molecular Biology 16 17%
Nursing and Health Professions 8 9%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Other 6 7%
Unknown 15 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2019.
All research outputs
#17,706,524
of 22,736,112 outputs
Outputs from BMC Cancer
#4,960
of 8,272 outputs
Outputs of similar age
#151,116
of 165,554 outputs
Outputs of similar age from BMC Cancer
#26
of 29 outputs
Altmetric has tracked 22,736,112 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,272 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 165,554 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.