Title |
Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study
|
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Published in |
BMC Cancer, November 2009
|
DOI | 10.1186/1471-2407-9-407 |
Pubmed ID | |
Authors |
Vibeke Andersen, Mette Østergaard, Jane Christensen, Kim Overvad, Anne Tjønneland, Ulla Vogel |
Abstract |
The xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH). Cyclooxygenase-2 (COX-2) derived prostaglandins promote gastrointestinal carcinogenesis, affecting angiogenesis, apoptosis, and invasiveness.The aim of this study was to investigate if polymorphisms in these genes were associated with risk of colorectal cancer (CRC), and to investigate possible interactions with lifestyle factors such as smoking, meat consumption, and NSAID use. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 2% |
Unknown | 90 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 26 | 28% |
Student > Ph. D. Student | 21 | 23% |
Researcher | 7 | 8% |
Student > Bachelor | 7 | 8% |
Student > Doctoral Student | 4 | 4% |
Other | 16 | 17% |
Unknown | 11 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 23 | 25% |
Medicine and Dentistry | 21 | 23% |
Biochemistry, Genetics and Molecular Biology | 16 | 17% |
Nursing and Health Professions | 8 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Other | 6 | 7% |
Unknown | 15 | 16% |