Title |
From inflammation to gastric cancer – the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases
|
---|---|
Published in |
Cell Communication and Signaling, April 2017
|
DOI | 10.1186/s12964-017-0171-4 |
Pubmed ID | |
Authors |
Silja Wessler, Linda M. Krisch, Dominik P. Elmer, Fritz Aberger |
Abstract |
Infections with the human pathogen Helicobacter pylori (H. pylori) are closely associated with the development of inflammatory disorders and neoplastic transformation of the gastric epithelium. Drastic changes in the micromilieu involve a complex network of H. pylori-regulated signal transduction pathways leading to the release of proinflammatory cytokines, gut hormones and a wide range of signaling molecules. Besides controlling embryonic development, the Hedgehog/GLI signaling pathway also plays important roles in epithelial proliferation, differentiation, and regeneration of the gastric physiology, but also in the induction and progression of inflammation and neoplastic transformation in H. pylori infections. Here, we summarize recent findings of H. pylori-associated Hedgehog/GLI signaling in gastric homeostasis, malignant development and the modulation of the gastric tumor microenvironment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Poland | 1 | 2% |
Unknown | 52 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 19% |
Student > Master | 8 | 15% |
Researcher | 8 | 15% |
Student > Doctoral Student | 5 | 9% |
Student > Bachelor | 5 | 9% |
Other | 6 | 11% |
Unknown | 11 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 17 | 32% |
Agricultural and Biological Sciences | 7 | 13% |
Medicine and Dentistry | 5 | 9% |
Immunology and Microbiology | 5 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 4 | 8% |
Unknown | 13 | 25% |