Title |
Antitumor activity of photodynamic therapy performed with nanospheres containing zinc-phthalocyanine
|
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Published in |
Journal of Nanobiotechnology, December 2013
|
DOI | 10.1186/1477-3155-11-41 |
Pubmed ID | |
Authors |
Flávia Arruda Portilho, Cláudio Eduardo deOliveira Cavalcanti, Ana Luisa Miranda-Vilela, Luciana Landim Carneiro Estevanato, João Paulo Figueiró Longo, Maria deFátimaMenezes Almeida Santos, Anamélia Lorenzetti Bocca, Olímpia Paschoal Martins, Andreza R Simioni, Paulo César Morais, Ricardo Bentes Azevedo, Antonio Claudio Tedesco, Zulmira GuerreroMarques Lacava |
Abstract |
The increasing incidence of cancer and the search for more effective therapies with minimal collateral effects have prompted studies to find alternative new treatments. Among these, photodynamic therapy (PDT) has been proposed as a very promising new modality in cancer treatment with the lowest rates of side effects, revealing itself to be particularly successful when the photosensitizer is associated with nanoscaled carriers. This study aimed to design and develop a new formulation based on albumin nanospheres containing zinc-phthalocyanine tetrasulfonate (ZnPcS4-AN) for use in the PDT protocol and to investigate its antitumor activity in Swiss albino mice using the Ehrlich solid tumor as an experimental model for breast cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Korea, Republic of | 1 | 2% |
Argentina | 1 | 2% |
Unknown | 64 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 14 | 21% |
Student > Ph. D. Student | 11 | 17% |
Student > Bachelor | 9 | 14% |
Researcher | 9 | 14% |
Professor > Associate Professor | 4 | 6% |
Other | 6 | 9% |
Unknown | 13 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 18% |
Agricultural and Biological Sciences | 10 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 9% |
Chemistry | 5 | 8% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Other | 11 | 17% |
Unknown | 18 | 27% |