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Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist

Overview of attention for article published in Respiratory Research, December 2013
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Title
Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist
Published in
Respiratory Research, December 2013
DOI 10.1186/1465-9921-14-137
Pubmed ID
Authors

Brian R Leaker, Peter J Barnes, Brian O’Connor

Abstract

Inhaled lipopolysaccharide (LPS) induces a dose-dependent, acute neutrophilic response in the airways of healthy volunteers that can be quantified in induced sputum. Chemokines, such as CXCL1 and CXCL8, play an important role in neutrophilic inflammation in the lung through the activation of CXCR2 and small molecule antagonists of these receptors have now been developed. We investigated the effect of AZD8309, a CXCR2 antagonist, compared with placebo on LPS-induced inflammation measured in sputum of healthy volunteers.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 70 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 27%
Student > Ph. D. Student 11 15%
Other 9 13%
Student > Bachelor 6 8%
Student > Master 4 6%
Other 10 14%
Unknown 12 17%
Readers by discipline Count As %
Medicine and Dentistry 24 34%
Agricultural and Biological Sciences 8 11%
Biochemistry, Genetics and Molecular Biology 6 8%
Immunology and Microbiology 5 7%
Nursing and Health Professions 4 6%
Other 11 15%
Unknown 13 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2013.
All research outputs
#20,655,488
of 25,373,627 outputs
Outputs from Respiratory Research
#2,702
of 3,062 outputs
Outputs of similar age
#245,334
of 321,194 outputs
Outputs of similar age from Respiratory Research
#22
of 31 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,062 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,194 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.