Title |
Phylogenetic relationship and virulence inference of Streptococcus Anginosus Group: curated annotation and whole-genome comparative analysis support distinct species designation
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Published in |
BMC Genomics, December 2013
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DOI | 10.1186/1471-2164-14-895 |
Pubmed ID | |
Authors |
Adam B Olson, Heather Kent, Christopher D Sibley, Margot E Grinwis, Philip Mabon, Claude Ouellette, Shari Tyson, Morag Graham, Shaun D Tyler, Gary Van Domselaar, Michael G Surette, Cindi R Corbett |
Abstract |
The Streptococcus Anginosus Group (SAG) represents three closely related species of the viridans group streptococci recognized as commensal bacteria of the oral, gastrointestinal and urogenital tracts. The SAG also cause severe invasive infections, and are pathogens during cystic fibrosis (CF) pulmonary exacerbation. Little genomic information or description of virulence mechanisms is currently available for SAG. We conducted intra and inter species whole-genome comparative analyses with 59 publically available Streptococcus genomes and seven in-house closed high quality finished SAG genomes; S. constellatus (3), S. intermedius (2), and S. anginosus (2). For each SAG species, we sequenced at least one numerically dominant strain from CF airways recovered during acute exacerbation and an invasive, non-lung isolate. We also evaluated microevolution that occurred within two isolates that were cultured from one individual one year apart. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
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Netherlands | 1 | 1% |
Sweden | 1 | 1% |
Germany | 1 | 1% |
Canada | 1 | 1% |
Unknown | 70 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 15 | 20% |
Student > Ph. D. Student | 14 | 19% |
Student > Master | 9 | 12% |
Student > Doctoral Student | 5 | 7% |
Student > Bachelor | 4 | 5% |
Other | 14 | 19% |
Unknown | 13 | 18% |
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Immunology and Microbiology | 13 | 18% |
Biochemistry, Genetics and Molecular Biology | 10 | 14% |
Medicine and Dentistry | 9 | 12% |
Nursing and Health Professions | 2 | 3% |
Other | 7 | 9% |
Unknown | 11 | 15% |