Title |
Polyploidy in myelofibrosis: analysis by cytogenetic and SNP array indicates association with advancing disease
|
---|---|
Published in |
Molecular Cytogenetics, December 2013
|
DOI | 10.1186/1755-8166-6-59 |
Pubmed ID | |
Authors |
Nisha R Singh, Christine M Morris, Mary Koleth, Kelly Wong, Christopher M Ward, William S Stevenson |
Abstract |
Myelofibrosis occurs as primary myelofibrosis or as a late occurrence in the evolution of essential thrombocythaemia and polycythaemia vera. It is the rarest of the three classic myeloproliferative neoplasms (MPN). Polyploidy has only rarely been reported in MPN despite the prominent involvement of abnormal megakaryocytes. The use of peripheral blood samples containing increased numbers of haematopoietic progenitors has improved the output from cytogenetic studies in myelofibrosis and together with the use of single nucleotide polymorphism arrays (SNPa) has contributed to an improved knowledge regarding the diverse genetic landscape of this rare disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 4 | 22% |
Student > Postgraduate | 3 | 17% |
Professor | 2 | 11% |
Researcher | 2 | 11% |
Student > Ph. D. Student | 1 | 6% |
Other | 2 | 11% |
Unknown | 4 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 39% |
Agricultural and Biological Sciences | 4 | 22% |
Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Unknown | 5 | 28% |