Title |
A moth pheromone brewery: production of (Z)-11-hexadecenol by heterologous co-expression of two biosynthetic genes from a noctuid moth in a yeast cell factory
|
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Published in |
Microbial Cell Factories, December 2013
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DOI | 10.1186/1475-2859-12-125 |
Pubmed ID | |
Authors |
Åsa K Hagström, Hong-Lei Wang, Marjorie A Liénard, Jean-Marc Lassance, Tomas Johansson, Christer Löfstedt |
Abstract |
Moths (Lepidoptera) are highly dependent on chemical communication to find a mate. Compared to conventional unselective insecticides, synthetic pheromones have successfully served to lure male moths as a specific and environmentally friendly way to control important pest species. However, the chemical synthesis and purification of the sex pheromone components in large amounts is a difficult and costly task. The repertoire of enzymes involved in moth pheromone biosynthesis in insecta can be seen as a library of specific catalysts that can be used to facilitate the synthesis of a particular chemical component. In this study, we present a novel approach to effectively aid in the preparation of semi-synthetic pheromone components using an engineered vector co-expressing two key biosynthetic enzymes in a simple yeast cell factory. |
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Mendeley readers
Geographical breakdown
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Environmental Science | 1 | 1% |
Other | 4 | 6% |
Unknown | 19 | 28% |