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Biarsenical ligands bind to endogenous G-protein α-subunits and enable allosteric sensing of nucleotide binding

Overview of attention for article published in BMC Molecular and Cell Biology, December 2013
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2 X users

Citations

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4 Dimensions

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18 Mendeley
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1 CiteULike
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Title
Biarsenical ligands bind to endogenous G-protein α-subunits and enable allosteric sensing of nucleotide binding
Published in
BMC Molecular and Cell Biology, December 2013
DOI 10.1186/1471-2091-14-37
Pubmed ID
Authors

Lauri Tõntson, Sergei Kopanchuk, Ago Rinken

Abstract

Heterotrimeric G-proteins relay extracellular signals to intracellular effector proteins. Multiple methods have been developed to monitor their activity; including labeled nucleotides and biosensors based on genetically engineered G-proteins. Here we describe a method for monitoring unlabeled nucleotide binding to endogenous G-proteins α-subunits in a homogeneous assay based on the interaction of 4',5'-bis(1,2,3-dithioarsolan-2-yl)-2',7'-difluorofluorescein (F2FlAsH) with G-protein α-subunits.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 39%
Student > Bachelor 2 11%
Student > Postgraduate 2 11%
Student > Ph. D. Student 2 11%
Professor 1 6%
Other 1 6%
Unknown 3 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 22%
Medicine and Dentistry 3 17%
Agricultural and Biological Sciences 2 11%
Neuroscience 2 11%
Social Sciences 1 6%
Other 1 6%
Unknown 5 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2013.
All research outputs
#17,235,658
of 25,373,627 outputs
Outputs from BMC Molecular and Cell Biology
#774
of 1,233 outputs
Outputs of similar age
#196,001
of 307,714 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#15
of 27 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 31st percentile – i.e., 31% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,714 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.