Title |
Wnt/beta-catenin pathway: modulating anticancer immune response
|
---|---|
Published in |
Journal of Hematology & Oncology, May 2017
|
DOI | 10.1186/s13045-017-0471-6 |
Pubmed ID | |
Authors |
Sachin Gopalkrishna Pai, Benedito A. Carneiro, Jose Mauricio Mota, Ricardo Costa, Caio Abner Leite, Romualdo Barroso-Sousa, Jason Benjamin Kaplan, Young Kwang Chae, Francis Joseph Giles |
Abstract |
Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal. The Wnt pathway mediates biological processes by a canonical or noncanonical pathway, depending on the involvement of β-catenin in signal transduction. β-catenin is a core component of the cadherin protein complex, whose stabilization is essential for the activation of Wnt/β-catenin signaling. As multiple aberrations in this pathway occur in numerous cancers, WNT-directed therapy represents an area of significant developmental therapeutics focus. The recently described role of Wnt/β-catenin pathway in regulating immune cell infiltration of the tumor microenvironment renewed the interest, given its potential impact on responses to immunotherapy treatments. This article summarizes the role of Wnt/β-catenin pathway in cancer and ongoing therapeutic strategies involving this pathway. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 33% |
United States | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Scientists | 1 | 33% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 724 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 105 | 15% |
Student > Ph. D. Student | 90 | 12% |
Student > Master | 75 | 10% |
Researcher | 69 | 10% |
Student > Doctoral Student | 39 | 5% |
Other | 88 | 12% |
Unknown | 258 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 205 | 28% |
Medicine and Dentistry | 69 | 10% |
Agricultural and Biological Sciences | 44 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 43 | 6% |
Immunology and Microbiology | 24 | 3% |
Other | 67 | 9% |
Unknown | 272 | 38% |