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Integrative analyses of gene expression and DNA methylation profiles in breast cancer cell line models of tamoxifen-resistance indicate a potential role of cells with stem-like properties

Overview of attention for article published in Breast Cancer Research, December 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • Good Attention Score compared to outputs of the same age and source (67th percentile)

Mentioned by

patent
2 patents
facebook
1 Facebook page

Citations

dimensions_citation
46 Dimensions

Readers on

mendeley
77 Mendeley
citeulike
2 CiteULike
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Title
Integrative analyses of gene expression and DNA methylation profiles in breast cancer cell line models of tamoxifen-resistance indicate a potential role of cells with stem-like properties
Published in
Breast Cancer Research, December 2013
DOI 10.1186/bcr3588
Pubmed ID
Authors

Xue Lin, Jian Li, Guangliang Yin, Qian Zhao, Daniel Elias, Anne E Lykkesfeldt, Jan Stenvang, Nils Brünner, Jun Wang, Huanming Yang, Lars Bolund, Henrik J Ditzel

Abstract

Development of resistance to tamoxifen is an important clinical issue in the treatment of breast cancer. Tamoxifen resistance may be the result of acquisition of epigenetic regulation within breast cancer cells, such as DNA methylation, resulting in changed mRNA expression of genes pivotal for estrogen-dependent growth. Alternatively, tamoxifen resistance may be due to selection of pre-existing resistant cells, or a combination of the two mechanisms.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 2 3%
Colombia 1 1%
Netherlands 1 1%
Austria 1 1%
Norway 1 1%
Kenya 1 1%
United States 1 1%
Unknown 69 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 21%
Student > Master 15 19%
Researcher 12 16%
Student > Doctoral Student 5 6%
Student > Bachelor 4 5%
Other 9 12%
Unknown 16 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 21 27%
Agricultural and Biological Sciences 15 19%
Medicine and Dentistry 12 16%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Environmental Science 2 3%
Other 7 9%
Unknown 18 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2022.
All research outputs
#5,338,984
of 25,373,627 outputs
Outputs from Breast Cancer Research
#624
of 2,052 outputs
Outputs of similar age
#58,980
of 320,503 outputs
Outputs of similar age from Breast Cancer Research
#11
of 34 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,052 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,503 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.