Title |
Monocyte depletion increases local proliferation of macrophage subsets after skeletal muscle injury
|
---|---|
Published in |
BMC Musculoskeletal Disorders, December 2013
|
DOI | 10.1186/1471-2474-14-359 |
Pubmed ID | |
Authors |
Claude H Côté, Patrice Bouchard, Nico van Rooijen, David Marsolais, Elise Duchesne |
Abstract |
Sequential accumulation of M1 and M2 macrophages is critical for skeletal muscle recovery after an acute injury. While M1 accumulation is believed to rely on monocyte infiltration, the mechanisms of M2 accumulation remain controversial, but could involve an infiltrating precursor. Yet, strong depletion of monocytes only partially impairs skeletal muscle healing, supporting the existence of alternative mechanisms to palliate the loss of infiltrating macrophage progenitors. The aims of this study are thus to investigate if proliferation occurs in macrophage subsets within injured skeletal muscles; and to determine if monocyte depletion leads to increased proliferation of macrophages after injury. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 1% |
Unknown | 74 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 26 | 35% |
Researcher | 14 | 19% |
Student > Master | 9 | 12% |
Student > Doctoral Student | 7 | 9% |
Student > Bachelor | 7 | 9% |
Other | 4 | 5% |
Unknown | 8 | 11% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 19 | 25% |
Medicine and Dentistry | 16 | 21% |
Biochemistry, Genetics and Molecular Biology | 10 | 13% |
Immunology and Microbiology | 6 | 8% |
Neuroscience | 5 | 7% |
Other | 8 | 11% |
Unknown | 11 | 15% |