Title |
Late thrombosis of a mitral bioprosthetic valve with associated massive left atrial thrombus
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Published in |
Echo Research & Practice, March 2017
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DOI | 10.1530/erp-17-0004 |
Pubmed ID | |
Authors |
Preetham R. Muskula, Rigoberto Ramirez, A. Michael Borkon, Michael L. Main |
Abstract |
An 84-year-old man presented 5 years following bioprosthetic mitral valve replacement with three months of worsening dyspnea on exertion. A new mitral stenosis murmur was noted on physical examination, and an electrocardiogram revealed newly recognized atrial fibrillation. Severe mitral stenosis (mean gradient = 13 mmHg) was confirmed by transthoracic echocardiography. Transesophageal echocardiography revealed markedly thickened mitral bioprosthetic leaflets with limited mobility, and a massive left atrial thrombus (> 4 cm in diameter) (see Figures 1A-D, and video files 1-4). Intravenous heparin was initiated, and 5 days later he was taken to the operating room for planned redo mitral valve replacement and left atrial thrombus extraction. Intraoperative transesophageal echocardiography revealed near complete resolution of the bioprosthetic leaflet thickening, and a mean mitral gradient of only 3 mmHg (see Figures 2A-C and multimedia files 5- 7). The patient underwent resection of the massive left atrial thrombus (see Figure 2D), but did not require redo mitral valve replacement. He was initiated on heparin (and transitioned to warfarin) early in the post-operative period, with complete resolution of dyspnea on exertion at 3 month follow-up. Bioprosthetic valve thrombosis is increasingly recognized as a cause of early prosthetic valve dysfunction (1, 2). This case illustrates that bioprosthetic valve thrombosis may occur years following valve replacement, therefore, any deterioration in the patients' clinical status (new onset dyspnea, heart failure, atrial fibrillation) warrants a thorough evaluation of the bioprosthetic valve with transesophageal echocardiography. In this case, initiation of anticoagulation obviated the need for redo mitral valve replacement. |
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Geographical breakdown
Country | Count | As % |
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United States | 12 | 19% |
United Kingdom | 5 | 8% |
Spain | 4 | 6% |
Venezuela, Bolivarian Republic of | 4 | 6% |
Italy | 2 | 3% |
Egypt | 2 | 3% |
Australia | 2 | 3% |
Ecuador | 2 | 3% |
Brazil | 1 | 2% |
Other | 12 | 19% |
Unknown | 18 | 28% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 45 | 70% |
Practitioners (doctors, other healthcare professionals) | 10 | 16% |
Scientists | 6 | 9% |
Science communicators (journalists, bloggers, editors) | 3 | 5% |