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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Albumin-based drug delivery: harnessing nature to cure disease
|
|---|---|
| Published in |
Molecular and Cellular Therapies, February 2016
|
| DOI | 10.1186/s40591-016-0048-8 |
| Pubmed ID | |
| Authors |
Maja Thim Larsen, Matthias Kuhlmann, Michael Lykke Hvam, Kenneth A. Howard |
| Abstract |
The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies. Albumin is a natural transport protein with multiple ligand binding sites, cellular receptor engagement, and a long circulatory half-life due to interaction with the recycling neonatal Fc receptor. Exploitation of these properties promotes albumin as an attractive candidate for half-life extension and targeted intracellular delivery of drugs attached by covalent conjugation, genetic fusions, association or ligand-mediated association. This review will give an overview of albumin-based products with focus on the natural biological properties and molecular interactions that can be harnessed for the design of a next-generation drug delivery platform. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 684 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 680 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 118 | 17% |
| Student > Master | 91 | 13% |
| Student > Bachelor | 88 | 13% |
| Researcher | 63 | 9% |
| Other | 32 | 5% |
| Other | 90 | 13% |
| Unknown | 202 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 113 | 17% |
| Chemistry | 100 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 71 | 10% |
| Agricultural and Biological Sciences | 48 | 7% |
| Medicine and Dentistry | 27 | 4% |
| Other | 96 | 14% |
| Unknown | 229 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2023.
All research outputs
#3,577,415
of 25,457,858 outputs
Outputs from Molecular and Cellular Therapies
#5
of 36 outputs
Outputs of similar age
#53,710
of 312,067 outputs
Outputs of similar age from Molecular and Cellular Therapies
#1
of 3 outputs
Altmetric has tracked 25,457,858 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 36 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one scored the same or higher as 31 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,067 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them