Title |
Highly precise protein-protein interaction prediction based on consensus between template-based and de novo docking methods
|
---|---|
Published in |
BMC Proceedings, December 2013
|
DOI | 10.1186/1753-6561-7-s7-s6 |
Pubmed ID | |
Authors |
Masahito Ohue, Yuri Matsuzaki, Takehiro Shimoda, Takashi Ishida, Yutaka Akiyama |
Abstract |
Elucidation of protein-protein interaction (PPI) networks is important for understanding disease mechanisms and for drug discovery. Tertiary-structure-based in silico PPI prediction methods have been developed with two typical approaches: a method based on template matching with known protein structures and a method based on de novo protein docking. However, the template-based method has a narrow applicable range because of its use of template information, and the de novo docking based method does not have good prediction performance. In addition, both of these in silico prediction methods have insufficient precision, and require validation of the predicted PPIs by biological experiments, leading to considerable expenditure; therefore, PPI prediction methods with greater precision are needed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 2 | 5% |
Spain | 1 | 3% |
Canada | 1 | 3% |
Unknown | 35 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 26% |
Researcher | 7 | 18% |
Student > Bachelor | 3 | 8% |
Professor > Associate Professor | 3 | 8% |
Student > Master | 3 | 8% |
Other | 7 | 18% |
Unknown | 6 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 16 | 41% |
Biochemistry, Genetics and Molecular Biology | 7 | 18% |
Computer Science | 4 | 10% |
Engineering | 2 | 5% |
Medicine and Dentistry | 2 | 5% |
Other | 2 | 5% |
Unknown | 6 | 15% |