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Highly precise protein-protein interaction prediction based on consensus between template-based and de novo docking methods

Overview of attention for article published in BMC Proceedings, December 2013
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Title
Highly precise protein-protein interaction prediction based on consensus between template-based and de novo docking methods
Published in
BMC Proceedings, December 2013
DOI 10.1186/1753-6561-7-s7-s6
Pubmed ID
Authors

Masahito Ohue, Yuri Matsuzaki, Takehiro Shimoda, Takashi Ishida, Yutaka Akiyama

Abstract

Elucidation of protein-protein interaction (PPI) networks is important for understanding disease mechanisms and for drug discovery. Tertiary-structure-based in silico PPI prediction methods have been developed with two typical approaches: a method based on template matching with known protein structures and a method based on de novo protein docking. However, the template-based method has a narrow applicable range because of its use of template information, and the de novo docking based method does not have good prediction performance. In addition, both of these in silico prediction methods have insufficient precision, and require validation of the predicted PPIs by biological experiments, leading to considerable expenditure; therefore, PPI prediction methods with greater precision are needed.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 2 5%
Spain 1 3%
Canada 1 3%
Unknown 35 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 26%
Researcher 7 18%
Student > Bachelor 3 8%
Professor > Associate Professor 3 8%
Student > Master 3 8%
Other 7 18%
Unknown 6 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 41%
Biochemistry, Genetics and Molecular Biology 7 18%
Computer Science 4 10%
Engineering 2 5%
Medicine and Dentistry 2 5%
Other 2 5%
Unknown 6 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2014.
All research outputs
#17,706,524
of 22,736,112 outputs
Outputs from BMC Proceedings
#256
of 374 outputs
Outputs of similar age
#222,252
of 306,076 outputs
Outputs of similar age from BMC Proceedings
#17
of 20 outputs
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