Title |
Spatial distribution of insulin-like growth factor binding protein-2 following hypoxic-ischemic injury
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Published in |
BMC Neuroscience, December 2013
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DOI | 10.1186/1471-2202-14-158 |
Pubmed ID | |
Authors |
Lauren Fletcher, Elif Isgor, Shane Sprague, Lindsey H Williams, Betty B Alajajian, David F Jimenez, Murat Digicaylioglu |
Abstract |
Insulin-like growth factor binding protein-2 (IGFBP-2) regulates the bioavailability, transportation, and localization of insulin-like growth factor-I (IGF-I), an effective neuroprotectant in animal stroke models especially when administered intranasally. Therefore, determining IGFBP-2's endogenous distribution in the normal and ischemic brain is essential in maximizing the neuroprotective potential of the intranasal IGF-I treatment approach. However, current data on IGFBP-2 is limited to mRNA and in situ hybridization studies. The purpose of this study was to determine if there are any changes in IGFBP-2 protein levels and distribution in ischemic brain and also to determine if IGFBPs play a role in the transportation of intranasally administered IGF-I into the brain. |
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Geographical breakdown
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Demographic breakdown
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Members of the public | 2 | 100% |
Mendeley readers
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Demographic breakdown
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Researcher | 7 | 19% |
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Student > Doctoral Student | 1 | 3% |
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Other | 1 | 3% |
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