Title |
Epidemiological and molecular characteristics of emergent dengue virus in Yunnan Province near the China-Myanmar-Laos border, 2013–2015
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Published in |
BMC Infectious Diseases, May 2017
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DOI | 10.1186/s12879-017-2401-1 |
Pubmed ID | |
Authors |
Ting-Song Hu, Hai-Lin Zhang, Yun Feng, Jian-Hua Fan, Tian Tang, Yong-Hua Liu, Liu Zhang, Xiao-Xiong Yin, Gang Chen, Hua-Chang Li, Jin Zu, Hong-Bin Li, Yuan-Yuan Li, Jing Yu, Fu-Qiang Zhang, Quan-Shui Fan |
Abstract |
Yunnan Province is located in southwestern China and neighbors the Southeast Asian countries, all of which are dengue-endemic areas. In 2000-2013, sporadic imported cases of dengue fever (DF) were reported almost annually in Yunnan Province. During 2013-2015, we confirmed that a large-scale indigenous DF outbreak emerged in cities of Yunnan Province near the China-Myanmar-Laos border. Epidemiological characteristics of DF in Yunnan Province during 2013-2015 were evaluated by retrospective analysis. A total of 232 dengue virus (DENV)-positive sera were randomly collected for sequence analysis of the capsid/premembrane region of DENV from patients with DF in Yunnan Province. The envelope gene of DENV isolates was also amplified and sequenced. Phylogenetic analyses were performed using the neighbor-joining method with the Tajima-Nei model. Phylogenetically, all DENV-positive samples could be classified into DENV-1 genotype I and DENV-2 Asian I genotype during 2013-2015 and DENV-4 genotype I in 2015 from Ruili City; and DENV-3 genotype II in 2013 and DENV-2 Cosmopolitan genotype in 2015 from Xishuangbanna Prefecture. Our results indicated that imported DF from patients from Laos and Myanmar was the primary cause of the DF epidemic in Yunnan Province. Additionally, DENV strains of all four serotypes were identified in indigenous cases in Yunnan Province during the same time period, while the dengue epidemic pattern observed in southwestern Yunnan showed characteristics of a hypoendemic nature: circulation of DENV-1 and DENV-2 over consecutive years. |
X Demographics
Geographical breakdown
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 65 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 10 | 15% |
Researcher | 9 | 14% |
Student > Bachelor | 7 | 11% |
Student > Ph. D. Student | 5 | 8% |
Student > Doctoral Student | 4 | 6% |
Other | 9 | 14% |
Unknown | 21 | 32% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 13 | 20% |
Medicine and Dentistry | 8 | 12% |
Immunology and Microbiology | 5 | 8% |
Agricultural and Biological Sciences | 5 | 8% |
Nursing and Health Professions | 3 | 5% |
Other | 9 | 14% |
Unknown | 22 | 34% |