Title |
Divergent transcription is associated with promoters of transcriptional regulators
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Published in |
BMC Genomics, December 2013
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DOI | 10.1186/1471-2164-14-914 |
Pubmed ID | |
Authors |
Cyrille Lepoivre, Mohamed Belhocine, Aurélie Bergon, Aurélien Griffon, Miriam Yammine, Laurent Vanhille, Joaquin Zacarias-Cabeza, Marc-Antoine Garibal, Frederic Koch, Muhammad Ahmad Maqbool, Romain Fenouil, Beatrice Loriod, Hélène Holota, Marta Gut, Ivo Gut, Jean Imbert, Jean-Christophe Andrau, Denis Puthier, Salvatore Spicuglia |
Abstract |
Divergent transcription is a wide-spread phenomenon in mammals. For instance, short bidirectional transcripts are a hallmark of active promoters, while longer transcripts can be detected antisense from active genes in conditions where the RNA degradation machinery is inhibited. Moreover, many described long non-coding RNAs (lncRNAs) are transcribed antisense from coding gene promoters. However, the general significance of divergent lncRNA/mRNA gene pair transcription is still poorly understood. Here, we used strand-specific RNA-seq with high sequencing depth to thoroughly identify antisense transcripts from coding gene promoters in primary mouse tissues. |
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France | 4 | 50% |
India | 1 | 13% |
Unknown | 3 | 38% |
Demographic breakdown
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Scientists | 3 | 38% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 3 | 2% |
Germany | 2 | 1% |
Japan | 2 | 1% |
Sweden | 1 | <1% |
Argentina | 1 | <1% |
Hungary | 1 | <1% |
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
Unknown | 141 | 92% |
Demographic breakdown
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Researcher | 39 | 25% |
Student > Master | 16 | 10% |
Student > Doctoral Student | 11 | 7% |
Student > Bachelor | 8 | 5% |
Other | 23 | 15% |
Unknown | 14 | 9% |
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Biochemistry, Genetics and Molecular Biology | 45 | 29% |
Medicine and Dentistry | 10 | 7% |
Computer Science | 3 | 2% |
Neuroscience | 2 | 1% |
Other | 6 | 4% |
Unknown | 19 | 12% |