Title |
The feline bile salt export pump: a structural and functional comparison with canine and human Bsep/BSEP
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Published in |
BMC Veterinary Research, December 2013
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DOI | 10.1186/1746-6148-9-259 |
Pubmed ID | |
Authors |
Cyrina D van Beusekom, Jeroen JMW van den Heuvel, Jan B Koenderink, Johannes A Schrickx, Frans GM Russel |
Abstract |
The bile salt export pump (BSEP/ABCB11) is the primary transporter for the excretion of bile acids from hepatocytes into bile. In human, inhibition of BSEP by drugs has been related to drug-induced cholestasis and subsequent cytotoxic effects. The role of BSEP in canine and feline liver diseases has not been studied in detail, but the same mechanism of inhibition by drugs as in humans could play a role in veterinary medicine. The aim of this study was to investigate the functional characteristics of feline Bsep in comparison with canine and human Bsep/BSEP with respect to substrate affinities and inhibitory potential of model drugs. Orthologs of all three species were cloned and cell membrane vesicles overexpressing feline, canine and human Bsep/BSEP were prepared for functional analyses. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 5 | 22% |
Student > Master | 4 | 17% |
Student > Ph. D. Student | 2 | 9% |
Student > Doctoral Student | 1 | 4% |
Professor | 1 | 4% |
Other | 4 | 17% |
Unknown | 6 | 26% |
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Pharmacology, Toxicology and Pharmaceutical Science | 5 | 22% |
Agricultural and Biological Sciences | 3 | 13% |
Medicine and Dentistry | 2 | 9% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Unspecified | 1 | 4% |
Other | 3 | 13% |
Unknown | 7 | 30% |