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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Absence of 4-1BB reduces obesity-induced atrophic response in skeletal muscle
|
|---|---|
| Published in |
Journal of Inflammation, May 2017
|
| DOI | 10.1186/s12950-017-0156-5 |
| Pubmed ID | |
| Authors |
Ngoc Hoan Le, Chu-Sook Kim, Thai Hien Tu, Byung-Sam Kim, Taesun Park, Jung Han Yoon Park, Tsuyoshi Goto, Teruo Kawada, Tae Youl Ha, Rina Yu |
| Abstract |
Obesity-induced inflammation causes skeletal muscle atrophy accompanied by disruption of oxidative metabolism and is implicated in metabolic complications such as insulin resistance and type 2 diabetes. We previously reported that 4-1BB, a member of the tumor necrosis factor receptor superfamily, participated in obesity-induced skeletal muscle inflammation. Here, we show that the absence of 4-1BB in obese mice fed a high-fat diet led to a decrease in expression of atrophic factors (MuRF1 and Atrogin-1) with suppression of NF-κB activity, and that this was accompanied by increases in mitochondrial oxidative metabolic genes/proteins (e.g., PGC-1α, CPT1β, etc.) expression and oxidative muscle fibers marker genes/proteins in the skeletal muscle. These findings suggest that 4-1BB-mediated inflammatory signaling could be a potential target for combating obesity-related muscle atrophy and metabolic derangement in skeletal muscle. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 43% |
| United States | 2 | 29% |
| Canada | 1 | 14% |
| Norway | 1 | 14% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 43% |
| Scientists | 2 | 29% |
| Science communicators (journalists, bloggers, editors) | 2 | 29% |
Mendeley readers
The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 12 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 33% |
| Student > Master | 1 | 8% |
| Unspecified | 1 | 8% |
| Student > Bachelor | 1 | 8% |
| Researcher | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 3 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 2 | 17% |
| Medicine and Dentistry | 2 | 17% |
| Biochemistry, Genetics and Molecular Biology | 2 | 17% |
| Veterinary Science and Veterinary Medicine | 1 | 8% |
| Agricultural and Biological Sciences | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 3 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2017.
All research outputs
#7,962,193
of 25,382,440 outputs
Outputs from Journal of Inflammation
#97
of 425 outputs
Outputs of similar age
#117,156
of 325,438 outputs
Outputs of similar age from Journal of Inflammation
#2
of 6 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 425 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,438 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.