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ING5 suppresses breast cancer progression and is regulated by miR-24

Overview of attention for article published in Molecular Cancer, May 2017
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Mentioned by

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3 tweeters

Citations

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17 Dimensions

Readers on

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20 Mendeley
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Title
ING5 suppresses breast cancer progression and is regulated by miR-24
Published in
Molecular Cancer, May 2017
DOI 10.1186/s12943-017-0658-z
Pubmed ID
Authors

Shufang Cui, Xin Liao, Chao Ye, Xin Yin, Minghui Liu, Yeting Hong, Mengchao Yu, Yanqing Liu, Hongwei Liang, Chen-Yu Zhang, Xi Chen

Abstract

The inhibitor of growth (ING) gene family of tumor suppressors is involved in multiple cellular functions such as cell cycle regulation, apoptosis, and chromatin remodeling. ING5 is a new member of the ING family whose function and regulation remain largely unknown. Quantitative real-time PCR and western blot were used to examine the expression levels of ING5 in breast cancer tissues. The miRNAs that potentially targeted ING5 were determined by bioinformatics analysis and luciferase reporter assay. Cell viability assay, transwell invasion and apoptosis assay were used to characterize the changes induced by overexpressing or knocking down miR-24 or ING5. Hematoxylin and eosin (H&E) staining and immunohistochemical staining for ING5 and Ki-67 were used for xenograft assays in BALB/c nude mice. We showed that the ING5 protein rather than the mRNA, was significantly downregulated in breast cancer tissues. We also investigated the potential function of ING5 in breast tumorigenesis and found that ING5 suppressed the proliferation and invasion of breast cancer cells and promoted their apoptosis. Furthermore, we explored the molecular mechanisms accounting for the dysregulation of ING5 in breast cancer cells and identified an oncomiR, miR-24, as a direct upstream regulator of ING5. We revealed that miR-24 had the opposite effects to those of ING5 on breast cancer cells and could accelerate xenografted tumor growth in vivo. Our findings uncover the tumor-suppressive role of ING5 and the regulatory pathway of ING5 in breast cancer and may provide insights into the molecular mechanisms of breast carcinogenesis.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 35%
Student > Ph. D. Student 2 10%
Student > Master 2 10%
Professor 1 5%
Student > Doctoral Student 1 5%
Other 4 20%
Unknown 3 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 20%
Sports and Recreations 4 20%
Medicine and Dentistry 4 20%
Agricultural and Biological Sciences 2 10%
Social Sciences 1 5%
Other 2 10%
Unknown 3 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2018.
All research outputs
#7,877,695
of 12,555,036 outputs
Outputs from Molecular Cancer
#576
of 1,059 outputs
Outputs of similar age
#147,784
of 260,332 outputs
Outputs of similar age from Molecular Cancer
#1
of 1 outputs
Altmetric has tracked 12,555,036 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,059 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them