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High dose intravenous iron, mineral homeostasis and intact FGF23 in normal and uremic rats

Overview of attention for article published in BMC Nephrology, December 2013
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Title
High dose intravenous iron, mineral homeostasis and intact FGF23 in normal and uremic rats
Published in
BMC Nephrology, December 2013
DOI 10.1186/1471-2369-14-281
Pubmed ID
Authors

Eva Gravesen, Jacob Hofman-Bang, Maria L Mace, Ewa Lewin, Klaus Olgaard

Abstract

High iron load might have a number of toxic effects in the organism. Recently intravenous (iv) iron has been proposed to induce elevation of fibroblast growth factor 23 (FGF23), hypophosphatemia and osteomalacia in iron deficient subjects. High levels of FGF23 are associated with increased mortality in the chronic kidney disease (CKD) population. CKD patients are often treated with iv iron therapy in order to maintain iron stores and erythropoietin responsiveness, also in the case of not being iron depleted. Therefore, the effect of a single high iv dose of two different iron preparations, iron isomaltoside 1000 (IIM) and ferric carboxymaltose (FCM), on plasma levels of FGF23 and phosphate was examined in normal and uremic iron repleted rats.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 3%
Australia 1 3%
Unknown 29 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 23%
Student > Master 4 13%
Student > Doctoral Student 3 10%
Student > Bachelor 3 10%
Student > Ph. D. Student 3 10%
Other 6 19%
Unknown 5 16%
Readers by discipline Count As %
Medicine and Dentistry 12 39%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Biochemistry, Genetics and Molecular Biology 2 6%
Agricultural and Biological Sciences 2 6%
Psychology 2 6%
Other 4 13%
Unknown 7 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2013.
All research outputs
#17,708,224
of 22,738,543 outputs
Outputs from BMC Nephrology
#1,700
of 2,461 outputs
Outputs of similar age
#221,839
of 306,082 outputs
Outputs of similar age from BMC Nephrology
#38
of 63 outputs
Altmetric has tracked 22,738,543 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,461 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,082 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.