Title |
Tocotrienols for normalisation of hepatic echogenic response in nonalcoholic fatty liver: a randomised placebo-controlled clinical trial
|
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Published in |
Nutrition Journal, December 2013
|
DOI | 10.1186/1475-2891-12-166 |
Pubmed ID | |
Authors |
Enrico Magosso, Mukhtar Alam Ansari, Yogheswaran Gopalan, Ibrahim Lutfi Shuaib, Jia-Woei Wong, Nurzalina Abdul Karim Khan, Mohamed Rizal Abu Bakar, Bee-Hong Ng, Kah-Hay Yuen |
Abstract |
Nonalcoholic fatty liver disease (NAFLD) is one of the commonest liver disorders. Obesity, insulin resistance, lipid peroxidation and oxidative stress have been identified amongst the possible hits leading to the onset and progression of this disease. Nutritional evaluation of NAFLD patients showed a lower-than-recommended intake of vitamin E. Vitamin E is a family of 8 isoforms, 4 tocopherols and 4 tocotrienols. Alpha-tocopherol has been widely investigated in liver diseases, whereas no previous clinical trial has investigated tocotrienols for NAFLD. Aim of the study was to determine the effects of mixed tocotrienols, in normalising the hepatic echogenic response in hypercholesterolaemic patients with ultrasound-proven NAFLD. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 38% |
Canada | 2 | 25% |
France | 1 | 13% |
Unknown | 2 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 50% |
Scientists | 2 | 25% |
Practitioners (doctors, other healthcare professionals) | 2 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Malaysia | 1 | <1% |
Singapore | 1 | <1% |
Unknown | 134 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 27 | 20% |
Researcher | 17 | 13% |
Student > Master | 14 | 10% |
Student > Ph. D. Student | 10 | 7% |
Student > Postgraduate | 10 | 7% |
Other | 25 | 18% |
Unknown | 33 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 37 | 27% |
Agricultural and Biological Sciences | 19 | 14% |
Biochemistry, Genetics and Molecular Biology | 13 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 7% |
Nursing and Health Professions | 8 | 6% |
Other | 14 | 10% |
Unknown | 36 | 26% |