Title |
microRNAs: important regulators of stem cells
|
---|---|
Published in |
Stem Cell Research & Therapy, May 2017
|
DOI | 10.1186/s13287-017-0551-0 |
Pubmed ID | |
Authors |
Na Li, Bo Long, Wei Han, Shumin Yuan, Kun Wang |
Abstract |
Stem cells are undifferentiated cells and have multi-lineage differentiation potential. Generally, stem cells are classified into adult stem cells, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Stem cells have great potential in clinical therapy due to their pluripotency and self-renewal ability. microRNAs (miRNAs) are small non-coding RNAs which are evolutionarily conserved and participate in the pathogenesis of many diseases, cell cycle regulation, apoptosis, aging, cell fate decisions, and different signaling pathways. Different kinds of stem cells possess distinct miRNA expression profiles. Our review summarizes the critical roles of miRNAs in stem cell reprogramming, pluripotency maintenance, and differentiation. In the future, miRNAs may greatly contribute to stem cell clinical therapy and have potential applications in regenerative medicine. |
X Demographics
Geographical breakdown
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Korea, Republic of | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | <1% |
Unknown | 151 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 20 | 13% |
Student > Bachelor | 17 | 11% |
Student > Master | 16 | 11% |
Researcher | 11 | 7% |
Student > Doctoral Student | 10 | 7% |
Other | 30 | 20% |
Unknown | 48 | 32% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 44 | 29% |
Agricultural and Biological Sciences | 18 | 12% |
Medicine and Dentistry | 12 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
Neuroscience | 5 | 3% |
Other | 17 | 11% |
Unknown | 51 | 34% |