Title |
Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice
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Published in |
Molecular Brain, June 2009
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DOI | 10.1186/1756-6606-2-19 |
Pubmed ID | |
Authors |
Koichi Tanda, Akinori Nishi, Naoki Matsuo, Kazuo Nakanishi, Nobuyuki Yamasaki, Tohru Sugimoto, Keiko Toyama, Keizo Takao, Tsuyoshi Miyakawa |
Abstract |
Neuronal nitric oxide synthase (nNOS) is involved in the regulation of a diverse population of intracellular messenger systems in the brain. In humans, abnormal NOS/nitric oxide metabolism is suggested to contribute to the pathogenesis and pathophysiology of some neuropsychiatric disorders, such as schizophrenia and bipolar disorder. Mice with targeted disruption of the nNOS gene exhibit abnormal behaviors. Here, we subjected nNOS knockout (KO) mice to a battery of behavioral tests to further investigate the role of nNOS in neuropsychiatric functions. We also examined the role of nNOS in dopamine/DARPP-32 signaling in striatal slices from nNOS KO mice and the effects of the administration of a dopamine D1 receptor agonist on behavior in nNOS KO mice. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 2 | 2% |
Germany | 2 | 2% |
United States | 2 | 2% |
Colombia | 1 | <1% |
Czechia | 1 | <1% |
India | 1 | <1% |
Japan | 1 | <1% |
Mexico | 1 | <1% |
Unknown | 96 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 23 | 21% |
Student > Ph. D. Student | 21 | 20% |
Student > Master | 11 | 10% |
Student > Bachelor | 8 | 7% |
Professor > Associate Professor | 8 | 7% |
Other | 22 | 21% |
Unknown | 14 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 32 | 30% |
Neuroscience | 20 | 19% |
Biochemistry, Genetics and Molecular Biology | 12 | 11% |
Medicine and Dentistry | 11 | 10% |
Psychology | 5 | 5% |
Other | 11 | 10% |
Unknown | 16 | 15% |