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Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice

Overview of attention for article published in Molecular Brain, June 2009
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Title
Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice
Published in
Molecular Brain, June 2009
DOI 10.1186/1756-6606-2-19
Pubmed ID
Authors

Koichi Tanda, Akinori Nishi, Naoki Matsuo, Kazuo Nakanishi, Nobuyuki Yamasaki, Tohru Sugimoto, Keiko Toyama, Keizo Takao, Tsuyoshi Miyakawa

Abstract

Neuronal nitric oxide synthase (nNOS) is involved in the regulation of a diverse population of intracellular messenger systems in the brain. In humans, abnormal NOS/nitric oxide metabolism is suggested to contribute to the pathogenesis and pathophysiology of some neuropsychiatric disorders, such as schizophrenia and bipolar disorder. Mice with targeted disruption of the nNOS gene exhibit abnormal behaviors. Here, we subjected nNOS knockout (KO) mice to a battery of behavioral tests to further investigate the role of nNOS in neuropsychiatric functions. We also examined the role of nNOS in dopamine/DARPP-32 signaling in striatal slices from nNOS KO mice and the effects of the administration of a dopamine D1 receptor agonist on behavior in nNOS KO mice.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 2%
Germany 2 2%
United States 2 2%
Colombia 1 <1%
Czechia 1 <1%
India 1 <1%
Japan 1 <1%
Mexico 1 <1%
Unknown 96 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 23 21%
Student > Ph. D. Student 21 20%
Student > Master 11 10%
Student > Bachelor 8 7%
Professor > Associate Professor 8 7%
Other 22 21%
Unknown 14 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 32 30%
Neuroscience 20 19%
Biochemistry, Genetics and Molecular Biology 12 11%
Medicine and Dentistry 11 10%
Psychology 5 5%
Other 11 10%
Unknown 16 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2014.
All research outputs
#14,770,397
of 22,738,543 outputs
Outputs from Molecular Brain
#624
of 1,103 outputs
Outputs of similar age
#93,279
of 110,598 outputs
Outputs of similar age from Molecular Brain
#5
of 6 outputs
Altmetric has tracked 22,738,543 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,103 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 110,598 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.