A 72-year-old woman presented with sepsis and lower limb ischaemia. Transoesophageal echocardiography (TOE) for suspected endocarditis revealed no cardiac pathology or source of emboli but a large thrombus-like mass was noted in a normal size descending aorta (Fig. 1A, Video 1). Repeat TOE after two weeks of anticoagulation showed two new masses and no change in the size of the original one (Fig. 1B). The patient died following bilateral leg amputation. There was no PM to provide pathology confirmation but the most likely diagnosis was of a thrombus, possibly infected. Large aortic clots in a mildly diseased aorta are unusual and a rare cause of systemic embolization1. TOE is considered the best imaging technique for aortic thrombi2 and in this case it clarified the correct diagnosis. A systematic TOE protocol3 with assessment of all structures including descending aorta should be followed irrespective of the original indication. In the present case a more focussed study might have missed the main pathology which was captured due to the thoroughness of the operator in completing the scan including all aortic views.