Title |
Distinct DNA methylation patterns of cognitive impairment and trisomy 21 in down syndrome
|
---|---|
Published in |
BMC Medical Genomics, December 2013
|
DOI | 10.1186/1755-8794-6-58 |
Pubmed ID | |
Authors |
Meaghan J Jones, Pau Farré, Lisa M McEwen, Julia L MacIsaac, Kim Watt, Sarah M Neumann, Eldon Emberly, Max S Cynader, Naznin Virji-Babul, Michael S Kobor |
Abstract |
The presence of an extra whole or part of chromosome 21 in people with Down syndrome (DS) is associated with multiple neurological changes, including pathological aging that often meets the criteria for Alzheimer's Disease (AD). In addition, trisomies have been shown to disrupt normal epigenetic marks across the genome, perhaps in response to changes in gene dosage. We hypothesized that trisomy 21 would result in global epigenetic changes across all participants, and that DS patients with cognitive impairment would show an additional epigenetic signature. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Denmark | 1 | 1% |
Unknown | 92 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 18 | 19% |
Student > Bachelor | 18 | 19% |
Student > Master | 13 | 14% |
Researcher | 13 | 14% |
Student > Doctoral Student | 5 | 5% |
Other | 15 | 16% |
Unknown | 11 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 29 | 31% |
Biochemistry, Genetics and Molecular Biology | 14 | 15% |
Medicine and Dentistry | 13 | 14% |
Neuroscience | 11 | 12% |
Nursing and Health Professions | 5 | 5% |
Other | 9 | 10% |
Unknown | 12 | 13% |