Title |
Molecular characterization and immune modulation properties of Clonorchis sinensis-derived RNASET2
|
---|---|
Published in |
Parasites & Vectors, December 2013
|
DOI | 10.1186/1756-3305-6-360 |
Pubmed ID | |
Authors |
Yanquan Xu, Wenjun Chen, Meng Bian, Xiaoyun Wang, Jiufeng Sun, Hengchang Sun, Feifei Jia, Chi Liang, Xuerong Li, Xiaonong Zhou, Yan Huang, Xinbing Yu |
Abstract |
Clonorchis sinensis (C. sinensis, Cs) is a trematode parasite that often causes chronic cumulative infections in the hepatobiliary ducts of the host and can lead to pathological changes by continuously released excretory/secretory proteins (ESPs). A T2 ribonuclease in trematode ESPs, has been identified as a potent regulator of dendritic cell (DCs) modulation. We wondered whether there was a counterpart present in CsESPs with similar activity. To gain a better understanding of CsESPs associated immune responses, we identified and characterized RNASET2 of C. sinensis (CsRNASET2) in this paper. |
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