Title |
The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum
|
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Published in |
Clinical Epigenetics, January 2014
|
DOI | 10.1186/1868-7083-6-1 |
Pubmed ID | |
Authors |
Melkaye G Melka, Benjamin I Laufer, Patrick McDonald, Christina A Castellani, Nagalingam Rajakumar, Richard O’Reilly, Shiva M Singh |
Abstract |
The mechanism of action of olanzapine in treating schizophrenia is not clear. This research reports the effects of a therapeutic equivalent treatment of olanzapine on DNA methylation in a rat model in vivo.Genome-wide DNA methylation was assessed using a MeDIP-chip analysis. All methylated DNA immunoprecipitation (MeDIP), sample labelling, hybridization and processing were performed by Arraystar Inc (Rockville, MD, USA). The identified gene promoters showing significant alterations to DNA methylation were then subjected to Ingenuity Pathway Analysis (Ingenuity System Inc, CA, USA). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 6 | 35% |
United States | 2 | 12% |
France | 1 | 6% |
Germany | 1 | 6% |
Argentina | 1 | 6% |
Spain | 1 | 6% |
India | 1 | 6% |
Unknown | 4 | 24% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 47% |
Scientists | 7 | 41% |
Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
China | 1 | 1% |
Canada | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 81 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 15% |
Researcher | 12 | 14% |
Student > Master | 12 | 14% |
Student > Bachelor | 9 | 11% |
Student > Postgraduate | 5 | 6% |
Other | 13 | 15% |
Unknown | 20 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 21% |
Medicine and Dentistry | 15 | 18% |
Biochemistry, Genetics and Molecular Biology | 12 | 14% |
Neuroscience | 11 | 13% |
Chemistry | 2 | 2% |
Other | 5 | 6% |
Unknown | 21 | 25% |