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The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum

Overview of attention for article published in Clinical Epigenetics, January 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

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17 X users
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2 Google+ users
reddit
1 Redditor

Citations

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59 Dimensions

Readers on

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84 Mendeley
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Title
The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum
Published in
Clinical Epigenetics, January 2014
DOI 10.1186/1868-7083-6-1
Pubmed ID
Authors

Melkaye G Melka, Benjamin I Laufer, Patrick McDonald, Christina A Castellani, Nagalingam Rajakumar, Richard O’Reilly, Shiva M Singh

Abstract

The mechanism of action of olanzapine in treating schizophrenia is not clear. This research reports the effects of a therapeutic equivalent treatment of olanzapine on DNA methylation in a rat model in vivo.Genome-wide DNA methylation was assessed using a MeDIP-chip analysis. All methylated DNA immunoprecipitation (MeDIP), sample labelling, hybridization and processing were performed by Arraystar Inc (Rockville, MD, USA). The identified gene promoters showing significant alterations to DNA methylation were then subjected to Ingenuity Pathway Analysis (Ingenuity System Inc, CA, USA).

X Demographics

X Demographics

The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 1%
Canada 1 1%
Brazil 1 1%
Unknown 81 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 15%
Researcher 12 14%
Student > Master 12 14%
Student > Bachelor 9 11%
Student > Postgraduate 5 6%
Other 13 15%
Unknown 20 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 21%
Medicine and Dentistry 15 18%
Biochemistry, Genetics and Molecular Biology 12 14%
Neuroscience 11 13%
Chemistry 2 2%
Other 5 6%
Unknown 21 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2014.
All research outputs
#3,021,569
of 25,654,806 outputs
Outputs from Clinical Epigenetics
#202
of 1,446 outputs
Outputs of similar age
#33,363
of 320,781 outputs
Outputs of similar age from Clinical Epigenetics
#2
of 8 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,446 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,781 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.