Title |
Tissue-resident lymphocytes: sentinel of the transformed tissue
|
---|---|
Published in |
Journal for Immunotherapy of Cancer, May 2017
|
DOI | 10.1186/s40425-017-0244-3 |
Pubmed ID | |
Authors |
Saïda Dadi, Ming O. Li |
Abstract |
Tumor cells can be detected and cleared by lymphocytes in a process termed cancer immunosurveillance. However, the contributing cell types had not been fully characterized. Using oncogene-induced murine models of epithelial cancer, a recent study showed that cell transformation triggers expansion of tissue-resident lymphocytes derived from innate, T cell receptor (TCR) αβ and TCRγδ lineages. These type-1-like innate lymphoid cells (ILC1ls) and type 1 innate-like T cells (ILTC1s) share a gene expression program distinct from those of conventional lymphocytes, and exhibit cytolytic activities against tumor cells. Further deciphering such a tumor-elicited immunosurveillance mechanism may 1 day be harnessed for novel cancer immunotherapy. |
X Demographics
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Country | Count | As % |
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United States | 3 | 30% |
Canada | 2 | 20% |
Italy | 2 | 20% |
Comoros | 1 | 10% |
Russia | 1 | 10% |
Unknown | 1 | 10% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 40% |
Scientists | 4 | 40% |
Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 3 | 18% |
Student > Master | 2 | 12% |
Researcher | 2 | 12% |
Student > Ph. D. Student | 2 | 12% |
Student > Doctoral Student | 1 | 6% |
Other | 2 | 12% |
Unknown | 5 | 29% |
Readers by discipline | Count | As % |
---|---|---|
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Immunology and Microbiology | 3 | 18% |
Nursing and Health Professions | 1 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Biochemistry, Genetics and Molecular Biology | 1 | 6% |
Other | 1 | 6% |
Unknown | 7 | 41% |