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Mendeley readers
Attention Score in Context
| Title |
Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis
|
|---|---|
| Published in |
Critical Care, January 2014
|
| DOI | 10.1186/cc13176 |
| Pubmed ID | |
| Authors |
Katherine Chang, Catherine Svabek, Cristina Vazquez-Guillamet, Bryan Sato, David Rasche, Strother Wilson, Paul Robbins, Nancy Ulbrandt, JoAnn Suzich, Jonathan Green, Andriani C Patera, Wade Blair, Subramaniam Krishnan, Richard Hotchkiss |
| Abstract |
A major pathophysiologic mechanism in sepsis is impaired host immunity which results in failure to eradicate invading pathogens and increased susceptibility to secondary infections. Although many immunosuppressive mechanisms exist, increased expression of the inhibitory receptor programmed cell death 1 (PD-1) and its ligand (PD-L1) are thought to play key roles. The newly recognized phenomenon of T cell exhaustion is mediated in part by PD-1 effects on T cells. This study tested the ability of anti-PD-1 and anti-PD-L1 antibodies to prevent apoptosis and improve lymphocyte function in septic patients. |
Mendeley readers
The data shown below were compiled from readership statistics for 154 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Colombia | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 150 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 29 | 19% |
| Student > Ph. D. Student | 26 | 17% |
| Student > Master | 18 | 12% |
| Student > Bachelor | 11 | 7% |
| Student > Postgraduate | 10 | 6% |
| Other | 26 | 17% |
| Unknown | 34 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 44 | 29% |
| Biochemistry, Genetics and Molecular Biology | 20 | 13% |
| Immunology and Microbiology | 19 | 12% |
| Agricultural and Biological Sciences | 19 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Other | 12 | 8% |
| Unknown | 36 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 December 2022.
All research outputs
#5,240,498
of 25,374,647 outputs
Outputs from Critical Care
#3,407
of 6,554 outputs
Outputs of similar age
#57,695
of 319,134 outputs
Outputs of similar age from Critical Care
#27
of 90 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,134 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.