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Oleanolic acid attenuates renal fibrosis in mice with unilateral ureteral obstruction via facilitating nuclear translocation of Nrf2

Overview of attention for article published in Nutrition & Metabolism, January 2014
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Title
Oleanolic acid attenuates renal fibrosis in mice with unilateral ureteral obstruction via facilitating nuclear translocation of Nrf2
Published in
Nutrition & Metabolism, January 2014
DOI 10.1186/1743-7075-11-2
Pubmed ID
Authors

Sungjin Chung, Hye Eun Yoon, Soo Jeong Kim, Sung Jun Kim, Eun Sil Koh, Yu Ah Hong, Cheol Whee Park, Yoon Sik Chang, Seok Joon Shin

Abstract

Renal interstitial fibrosis is a common final pathological process in the progression of kidney disease. This is primarily due to oxidative stress, which contributes to renal inflammation and fibrosis. Nuclear factor-erythroid-2-related factor 2 (Nrf2) is known to coordinate induction of genes that encode antioxidant enzymes. We investigated the effects of oleanolic acid, a known Nrf2 activator, on oxidative stress-induced renal inflammation and fibrosis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 3%
Unknown 36 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 11%
Professor > Associate Professor 4 11%
Researcher 4 11%
Student > Ph. D. Student 4 11%
Student > Doctoral Student 3 8%
Other 6 16%
Unknown 12 32%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 24%
Medicine and Dentistry 5 14%
Biochemistry, Genetics and Molecular Biology 2 5%
Computer Science 1 3%
Veterinary Science and Veterinary Medicine 1 3%
Other 2 5%
Unknown 17 46%