Title |
Autoinflammatory diseases: a possible cause of thrombosis?
|
---|---|
Published in |
Thrombosis Journal, May 2015
|
DOI | 10.1186/s12959-015-0049-x |
Pubmed ID | |
Authors |
Micaela La Regina, Francesco Orlandini, Raffaele Manna |
Abstract |
Autoinflammatory diseases are a group of disorders due to acquired or hereditary disfunction of innate immune system and characterized by systemic or localized manifestations. The prototype is Familial Mediterranean Fever, a monogenic hereditary disorder, whose causing gene (MeFV gene) was identified in 1997 and opened the way to a new fascinanting chapter of rheumatology. A growing body of monogenic and poligenic autoinflammatory disorders has been described since then. Arterial and venous thrombosis is a common medical problem, with significant morbidity and mortality. Strong evidences from basic research and clinical epidemiological studies support the theory that inflammation and thrombosis can be associated. Because of their recurrent/chronic inflammatory nature, autoinflammatory diseases are a putative cause of thrombotic manifestations. In the present work, we reviewed the available evidences about monogenic autoinflammatory disorders, complicated by thrombotic manifestations. |
X Demographics
Geographical breakdown
Country | Count | As % |
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India | 1 | 9% |
United States | 1 | 9% |
Unknown | 9 | 82% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 9 | 82% |
Practitioners (doctors, other healthcare professionals) | 2 | 18% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 3% |
Unknown | 34 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 6 | 17% |
Student > Bachelor | 5 | 14% |
Researcher | 5 | 14% |
Student > Doctoral Student | 4 | 11% |
Student > Master | 4 | 11% |
Other | 6 | 17% |
Unknown | 5 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 54% |
Biochemistry, Genetics and Molecular Biology | 4 | 11% |
Agricultural and Biological Sciences | 2 | 6% |
Linguistics | 1 | 3% |
Computer Science | 1 | 3% |
Other | 1 | 3% |
Unknown | 7 | 20% |