Title |
Pulmonary renal syndrome in a child with coexistence of anti-neutrophil cytoplasmic antibodies and anti-glomerular basement membrane disease: case report and literature review
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Published in |
BMC Nephrology, March 2013
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DOI | 10.1186/1471-2369-14-66 |
Pubmed ID | |
Authors |
Radovan Bogdanović, Predrag Minić, Jasmina Marković-Lipkovski, Nataša Stajić, Nataša Savić, Milan Rodić |
Abstract |
Pulmonary renal syndrome (PRS), denoting the presence of diffuse alveolar hemorrhage and glomerulonephritis as manifestations of systemic autoimmune disease, is very rare in childhood. The coexistence of circulating anti-neutrophil cytoplasmic antibody (ANCA) and anti-glomerular basement membrane (GBM) disease in children affected by this syndrome is exceptional, with unfavorable outcome in five out of seven patients reported to date. We describe a child with PRS associated with both circulating anti-myeloperoxidase (anti-MPO) ANCA and anti-GBM disease on renal biopsy who was successfully treated with immunosuppressive therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 2 | 40% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 3% |
Ecuador | 1 | 3% |
Germany | 1 | 3% |
Unknown | 29 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Postgraduate | 5 | 16% |
Student > Master | 4 | 13% |
Student > Bachelor | 4 | 13% |
Student > Ph. D. Student | 2 | 6% |
Other | 2 | 6% |
Other | 7 | 22% |
Unknown | 8 | 25% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 15 | 47% |
Agricultural and Biological Sciences | 2 | 6% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Mathematics | 1 | 3% |
Unspecified | 1 | 3% |
Other | 3 | 9% |
Unknown | 9 | 28% |