Title |
Exhaled breath condensate in intubated neonates- a window into the lung’s glutathione status
|
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Published in |
Respiratory Research, January 2014
|
DOI | 10.1186/1465-9921-15-1 |
Pubmed ID | |
Authors |
Maria I Rosso, Susan Roark, Esther Taylor, XiaoDu Ping, Janine M Ward, Katherine Roche, Courtney McCracken, Lou Ann S Brown, Theresa W Gauthier |
Abstract |
Analysis of exhaled breath condensates (EBC) is a non-invasive technique to evaluate biomarkers such as antioxidants in the pediatric population, but limited data exists of its use in intubated patients, particularly newborns. Currently, tracheal aspirate (TA) serves as the gold standard collection modality in critically ill newborns, but this method remains invasive. We tested the hypothesis that glutathione status would positively correlate between EBC and TA collections in intubated newborns in the Newborn Intensive Care Unit (NICU). We also hypothesized that these measurements would be associated with alveolar macrophage (AM) glutathione status in the newborn lung. |
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