Title |
Long-term results of early adjuvant concurrent chemoradiotherapy for high-risk, early stage uterine cervical cancer patients after radical hysterectomy
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Published in |
BMC Cancer, April 2017
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DOI | 10.1186/s12885-017-3299-0 |
Pubmed ID | |
Authors |
Sang-Won Kim, Mison Chun, Hee-Sug Ryu, Suk-Joon Chang, Tae Wook Kong, Young-Taek Oh, Seung Hee Kang |
Abstract |
The aim of the present study was to investigate the long-term survival outcomes and toxicities associated with our experienced early administration of adjuvant concurrent chemoradiotherapy (CCRT). Ninety-eight patients with pelvic lymph node metastasis, positive resection margin, and/or parametrial invasion who received adjuvant CCRT between 1995 and 2011 were analyzed retrospectively. The first cycle of platinum-based adjuvant chemotherapy was initiated within 2-3 weeks after surgery (median, 12 days) and continued every 4 weeks for a total of 4 cycles. Adjuvant radiotherapy was performed during the second and third cycles of chemotherapy. After a median follow-up period of 119 months for survivors, 13 patients (13.3%) experienced recurrence and 11 patients died of cancer during the follow-up period. The 5-year recurrence-free survival and cancer specific survival rates were 87.6% and 90.6%, respectively. Ninety-four patients (95.9%) received ≥3 cycles of chemotherapy. Total radiation dose of ≥45 Gy was delivered in 91 patients (92.9%). Grade 3-4 hematologic and gastrointestinal toxicities developed in 37 (37.8%) and 14 (14.3%) patients during CCRT, respectively. The present study confirmed the long-term safety and encouraging survival outcomes of early administration of adjuvant CCRT, suggesting the benefits of early time to initiation of adjuvant treatments. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 27% |
Student > Doctoral Student | 2 | 13% |
Student > Bachelor | 2 | 13% |
Student > Postgraduate | 2 | 13% |
Student > Ph. D. Student | 1 | 7% |
Other | 2 | 13% |
Unknown | 2 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 53% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Psychology | 1 | 7% |
Nursing and Health Professions | 1 | 7% |
Unknown | 4 | 27% |