Title |
Identification of prognostic relevant chromosomal abnormalities in chronic lymphocytic leukemia using microarray-based genomic profiling
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Published in |
Molecular Cytogenetics, January 2014
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DOI | 10.1186/1755-8166-7-3 |
Pubmed ID | |
Authors |
Marian JPL Stevens-Kroef, Eva van den Berg, Daniel Olde Weghuis, Ad Geurts van Kessel, Rolph Pfundt, Matty Linssen-Wiersma, Marloes Benjamins, Trijnie Dijkhuizen, Patricia JTA Groenen, Annet Simons |
Abstract |
Characteristic genomic abnormalities in patients with B cell chronic lymphocytic leukemia (CLL) have been shown to provide important prognostic information. Fluorescence in situ hybridization (FISH) and multiplex ligation-dependent probe amplification (MLPA), currently used in clinical diagnostics of CLL, are targeted tests aimed at specific genomic loci. Microarray-based genomic profiling is a new high-resolution tool that enables genome-wide analyses. The aim of this study was to compare two recently launched genomic microarray platforms, i.e., the CytoScan HD Array (Affymetrix) and the HumanOmniExpress Array (Illumina), with FISH and MLPA to ascertain whether these latter tests can be replaced by either one of the microarray platforms in a clinical diagnostic setting. |
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Netherlands | 1 | 50% |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
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Portugal | 1 | 5% |
Brazil | 1 | 5% |
Unknown | 18 | 90% |
Demographic breakdown
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Student > Ph. D. Student | 5 | 25% |
Researcher | 4 | 20% |
Student > Bachelor | 3 | 15% |
Student > Doctoral Student | 2 | 10% |
Student > Postgraduate | 2 | 10% |
Other | 3 | 15% |
Unknown | 1 | 5% |
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Philosophy | 1 | 5% |
Unknown | 2 | 10% |