Title |
Behavioral changes following PCB 153 exposure in the Spontaneously Hypertensive rat – an animal model of Attention-Deficit/Hyperactivity disorder
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Published in |
Behavioral and Brain Functions, January 2014
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DOI | 10.1186/1744-9081-10-1 |
Pubmed ID | |
Authors |
Espen Borgå Johansen, Frode Fonnum, Per L Lausund, S Ivar Walaas, Nora Elise Bærland, Grete Wøien, Terje Sagvolden |
Abstract |
Attention-Deficit/Hyperactivity Disorder (ADHD) is a behavioral disorder affecting 3-5% of children. Although ADHD is highly heritable, environmental factors like exposure during early development to various toxic substances like polychlorinated biphenyls (PCBs) may contribute to the prevalence. PCBs are a group of chemical industrial compounds with adverse effects on neurobiological and cognitive functioning, and may produce behavioral impairments that share significant similarities with ADHD. The present study examined the relation between exposure to PCB 153 and changes in ADHD-like behavior in an animal model of ADHD, the spontaneously hypertensive rats (SHR/NCrl), and in Wistar Kyoto (WKY/NHsd) controls. |
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Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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United States | 1 | 3% |
Unknown | 39 | 98% |
Demographic breakdown
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Researcher | 5 | 13% |
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Student > Bachelor | 3 | 8% |
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Neuroscience | 4 | 10% |
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Other | 5 | 13% |
Unknown | 10 | 25% |