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Early-onset colorectal cancer patients without family history are “at very low risk” for lynch syndrome

Overview of attention for article published in Journal of Experimental & Clinical Cancer Research, January 2014
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Title
Early-onset colorectal cancer patients without family history are “at very low risk” for lynch syndrome
Published in
Journal of Experimental & Clinical Cancer Research, January 2014
DOI 10.1186/1756-9966-33-1
Pubmed ID
Authors

Vittoria Stigliano, Lupe Sanchez-Mete, Aline Martayan, Maria Diodoro, Beatrice Casini, Isabella Sperduti, Marcello Anti

Abstract

Several studies evaluated the prevalence of Lynch Syndrome (LS) in young onset colorectal cancer (CRC) patients and the results were extremely variable (5%-20%). Immunohistochemistry (IHC) for MMR proteins and/or MSI analysis are screening tests that are done, either by themselves or in conjunction, on colon cancer tissue to identify individuals at risk for LS. The primary aim of our study was to evaluate the prevalence of LS in a large series of early-onset CRC without family history compared with those with family history. The secondary aim was to assess the diagnostic accuracy of IHC and MSI analysis as pre-screening tools for LS.

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 50 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 24%
Student > Bachelor 8 16%
Student > Master 6 12%
Student > Ph. D. Student 5 10%
Other 4 8%
Other 11 22%
Unknown 4 8%
Readers by discipline Count As %
Medicine and Dentistry 29 58%
Biochemistry, Genetics and Molecular Biology 6 12%
Agricultural and Biological Sciences 4 8%
Nursing and Health Professions 1 2%
Unspecified 1 2%
Other 4 8%
Unknown 5 10%