Title |
Beyond cleaved small RNA targets: unraveling the complexity of plant RNA degradome data
|
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Published in |
BMC Genomics, January 2014
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DOI | 10.1186/1471-2164-15-15 |
Pubmed ID | |
Authors |
Cheng-Yu Hou, Ming-Tsung Wu, Shin-Hua Lu, Yue-Ie Hsing, Ho-Ming Chen |
Abstract |
Degradation is essential for RNA maturation, turnover, and quality control. RNA degradome sequencing that integrates a modified 5'-rapid amplification of cDNA ends protocol with next-generation sequencing technologies is a high-throughput approach for profiling the 5'-end of uncapped RNA fragments on a genome-wide scale. The primary application of degradome sequencing has been to identify the truncated transcripts that result from endonucleolytic cleavage guided by microRNAs or small interfering RNAs. As many pathways are involved in RNA degradation, degradome data should contain other RNA species besides the cleavage remnants of small RNA targets. Nevertheless, no systematic approaches have been established to explore the hidden complexity of plant degradome. |
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France | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
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Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
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Researcher | 32 | 39% |
Student > Ph. D. Student | 20 | 24% |
Student > Master | 9 | 11% |
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Professor > Associate Professor | 3 | 4% |
Other | 7 | 9% |
Unknown | 4 | 5% |
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Arts and Humanities | 1 | 1% |
Other | 1 | 1% |
Unknown | 6 | 7% |