Title |
On the stability of the Bayenv method in assessing human SNP-environment associations
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Published in |
Human Genomics, January 2014
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DOI | 10.1186/1479-7364-8-1 |
Pubmed ID | |
Authors |
Lily M Blair, Julie M Granka, Marcus W Feldman |
Abstract |
Phenotypic variation along environmental gradients has been documented among and within many species, and in some cases, genetic variation has been shown to be associated with these gradients. Bayenv is a relatively new method developed to detect patterns of polymorphisms associated with environmental gradients. Using a Bayesian Markov Chain Monte Carlo (MCMC) approach, Bayenv evaluates whether a linear model relating population allele frequencies to environmental variables is more probable than a null model based on observed frequencies of neutral markers. Although this method has been used to detect environmental adaptation in a number of species, including humans, plants, fish, and mosquitoes, stability between independent runs of this MCMC algorithm has not been characterized. In this paper, we explore the variability of results between runs and the factors contributing to it. |
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Members of the public | 1 | 50% |
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Researcher | 21 | 20% |
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