Title |
Pregnancy-associated breast cancers are driven by differences in adipose stromal cells present during lactation
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Published in |
Breast Cancer Research, January 2014
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DOI | 10.1186/bcr3594 |
Pubmed ID | |
Authors |
Jessica McCready, Lisa M Arendt, Eugene Glover, Vandana Iyer, Jerrica L Briendel, Stephen R Lyle, Stephen P Naber, Daniel G Jay, Charlotte Kuperwasser |
Abstract |
The prognosis of breast cancer is strongly influenced by the developmental stage of the breast when the tumor is diagnosed. Pregnancy-associated breast cancers (PABCs), cancers diagnosed during pregnancy, lactation, or in the first postpartum year, are typically found at an advanced stage, are more aggressive and have a poorer prognosis. Although the systemic and microenvironmental changes that occur during post-partum involution have been best recognized for their role in the pathogenesis of PABCs, epidemiological data indicate that PABCs diagnosed during lactation have an overall poorer prognosis than those diagnosed during involution. Thus, the physiologic and/or biological events during lactation may have a significant and unrecognized role in the pathobiology of PABCs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Bangladesh | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 3% |
Norway | 1 | 2% |
Unknown | 58 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 13 | 21% |
Student > Ph. D. Student | 9 | 15% |
Student > Bachelor | 6 | 10% |
Student > Doctoral Student | 5 | 8% |
Other | 5 | 8% |
Other | 12 | 20% |
Unknown | 11 | 18% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 15 | 25% |
Biochemistry, Genetics and Molecular Biology | 12 | 20% |
Agricultural and Biological Sciences | 7 | 11% |
Nursing and Health Professions | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Other | 8 | 13% |
Unknown | 13 | 21% |